Giannis Antetokounmpo had 44 points and 14 rebounds and Milwaukee overcame an electric performance by Wembanyama on his 20th birthday to beat San Antonio 125-121 on Thursday night.
Wembanyama had 27 points, and Devin Vassell led the Spurs with 34.
Giannis drops 44 as Bucks top Spurs in thriller
