Week 3 of the NFL closes the Sunday afternoon slate with an NFC West showdown as the Arizona Cardinals visit the San Francisco 49ers at Levi’s Stadium. Both teams bring divisional stakes to the table, and fans across the country will be tuned in. Here’s your full guide on how to watch, streaming options, and the latest betting odds.
Game Information
- Matchup: Arizona Cardinals at San Francisco 49ers
- Date & Time: Sunday, Sept. 21 at 4:25 p.m. ET
- Venue: Levi’s Stadium — Santa Clara, CA
How to Watch Cardinals vs 49ers
- TV Channel: FOX (check local listings)
- Streaming (in-market viewers): Fubo – Stream Now
- Streaming (out-of-market Sunday afternoon games): NFL Sunday Ticket from YouTube – Stream Now
- Tickets: Planning to go? Get seats on StubHub
Cardinals vs 49ers Odds (via BetMGM)
- Point Spread: 49ers -1.5 (-110), Cardinals +1.5 (-110)
- Moneyline: San Francisco -120 | Arizona +100
- Over/Under Total: 43.5
- Over Odds: -110
- Under Odds: -110
What to Expect
The 49ers are slim favorites at home, holding a -1.5 spread against their division rivals. San Francisco’s defense will look to slow down Arizona’s offense, while the Cardinals aim to steal a key road win in the NFC West race. With the total set at 43.5 points, oddsmakers expect a moderately low-scoring contest where execution and turnovers could decide the outcome.