The San Francisco 49ers return home to Levi’s Stadium for a highly anticipated Week 4 matchup against the Jacksonville Jaguars. With both teams aiming to solidify their place as playoff contenders, this late-afternoon kickoff is one of the marquee games of the week.
Jaguars vs. 49ers Game Information
- Date: Sunday, September 28, 2025
- Kickoff Time: 4:05 p.m. ET
- Venue: Levi’s Stadium – Santa Clara, California
- Forecast: 77°F and sunny (AccuWeather)
How to Watch Jaguars vs. 49ers
- TV Broadcast: FOX (national coverage in select markets)
- Streaming Options: Available through FOX Sports app, NFL+, YouTube TV, and Fubo (market-dependent availability)
Fans outside of the market can also access coverage through NFL Sunday Ticket on YouTube TV.
What to Watch For
- San Francisco 49ers: The 49ers will look to dominate the trenches with their elite defensive line while relying on their balanced offensive attack led by Christian McCaffrey and Brock Purdy.
- Jacksonville Jaguars: Trevor Lawrence and the Jaguars bring explosive playmaking ability on offense and will need to protect against San Francisco’s relentless pass rush to have a chance on the road.
This interconference battle could be a playoff preview, with both teams expected to contend deep into January.
Conclusion
Don’t miss the Jacksonville Jaguars vs. San Francisco 49ers in Week 4 of the 2025 NFL season. Kickoff is set for 4:05 p.m. ET on Sunday, September 28, live from Levi’s Stadium in Santa Clara. Watch on FOX, stream on NFL+, YouTube TV, or Fubo, and catch one of the weekend’s biggest showdowns as two rising powers in the AFC and NFC collide.