Week 5 of the NFL season wraps up under the lights of Monday Night Football as the Kansas City Chiefs (2-2) visit the Jacksonville Jaguars (3-1) at EverBank Stadium. Patrick Mahomes and Trevor Lawrence headline a primetime quarterback duel with AFC playoff implications.
Game Information
- Matchup: Kansas City Chiefs at Jacksonville Jaguars
- Date & Time: Monday, October 6, 2025 – 8:15 p.m. ET
- Venue: EverBank Stadium – Jacksonville, FL
- Weather: 78°F with showers possible (via AccuWeather)
- TV Channel: ABC, ESPN
Betting Odds (via ESPN BET Sportsbook)
- Spread: Chiefs -3.5 (-115) | Jaguars +3.5 (-105)
- Moneyline: Chiefs -195 | Jaguars +165
- Total (Over/Under): 46.5 points (Over -105, Under -115)
Kansas City opened as a slight favorite, but Jacksonville’s hot start makes this one of the most anticipated MNF clashes of the season.
Season Leaders
Kansas City Chiefs
- Passing: QB Patrick Mahomes – 939 yards, 7 TDs, 1 INT (87/142)
- Rushing: QB Patrick Mahomes – 130 yards, 2 TDs (22 carries)
- Receiving: WR Hollywood Brown – 209 yards, 1 TD (22 catches)
- Defense: DE George Karlaftis – 3 sacks
Jacksonville Jaguars
- Passing: QB Trevor Lawrence – 845 yards, 5 TDs, 4 INTs (84/144)
- Rushing: RB Travis Etienne Jr. – 394 yards, 2 TDs (65 carries)
- Receiving: TE Brenton Strange – 182 yards (19 catches)
- Defense: DT Arik Armstead – 2.5 sacks
Key Storylines
- Mahomes Doing It All: Not only leading the Chiefs in passing, Mahomes also paces the team in rushing yards, highlighting Kansas City’s offensive struggles beyond his heroics.
- Etienne’s Hot Start: The Jaguars’ RB has been a workhorse, already tallying nearly 400 rushing yards in four games. He’ll be crucial against Kansas City’s front.
- QB Duel in Primetime: Mahomes vs. Lawrence is a marquee AFC quarterback matchup that could swing seeding in the playoff race.
- Turnover Battle: Lawrence has four interceptions through four games; limiting mistakes will be vital if the Jaguars want to protect home field.
Prediction Outlook
The Chiefs’ experience in big moments and Mahomes’ ability to take over games give them the edge, but Jacksonville’s balance on offense and strong start make them dangerous at home. Expect a competitive Monday night showdown likely decided in the fourth quarter.