Two of the AFC’s biggest heavyweights meet again as Patrick Mahomes and the Kansas City Chiefs (5–3) face Josh Allen and the Buffalo Bills (5–2) on Sunday, November 2, 2025, at Highmark Stadium in Orchard Park, New York. This highly anticipated matchup could have major playoff implications — and it’s one fans won’t want to miss.
Game Information
- Matchup: Kansas City Chiefs vs. Buffalo Bills
- Date: Sunday, November 2, 2025
- Time: 4:25 PM ET
- Venue: Highmark Stadium — Orchard Park, NY
- Temperature: 45°F (via AccuWeather)
- TV Channel: CBS
How to Watch
- TV: CBS
- Streaming: Paramount+ (with CBS access) or the CBS Sports App
- Tickets: Buy Bills Tickets on VividSeats — starting at $326
This game headlines CBS’s late-afternoon broadcast window, drawing national attention as two elite quarterbacks renew one of the NFL’s most thrilling rivalries.
Betting Odds (via ESPN Bet Sportsbook)
- Spread: Chiefs –1.5 (–105) | Bills +1.5 (–115)
- Moneyline: Chiefs –120 | Bills EVEN
- Total (Over/Under): 51.5 points
- Over: –120
- Under: EVEN
According to ESPN Analytics, the Chiefs hold a 55.8% chance to win, while the Bills sit at 43.8%, underscoring how close this matchup is projected to be.
Team Leaders
| Category | Kansas City Chiefs | Buffalo Bills |
|---|---|---|
| Passing Yards | P. Mahomes – 2,099 (17 TD, 4 INT) | J. Allen – 1,560 (12 TD, 4 INT) |
| Rushing Yards | I. Pacheco – 329 (1 TD) | J. Cook III – 753 (7 TD) |
| Receiving Yards | T. Kelce – 474 (3 TD) | K. Shakir – 356 (3 TD) |
| Sacks | G. Karlaftis – 4.5 | J. Bosa – 3 |
Key Storylines
- Mahomes vs. Allen, Part VII: This rivalry has quickly become one of the NFL’s defining quarterback matchups. Both Mahomes and Allen enter Week 9 in top form, with Mahomes surpassing 2,000 yards and Allen accounting for nearly all of Buffalo’s offensive production.
- Bills’ ground game surging: Running back James Cook III has been the Bills’ most consistent weapon, already surpassing 750 rushing yards with 7 touchdowns on the season.
- Chiefs’ defensive edge: Kansas City’s pass rush, led by George Karlaftis (4.5 sacks), will look to pressure Allen early and often — especially in cold conditions at Highmark Stadium.
- Weather factor: With kickoff temperatures around 45°F, wind and late-fall conditions could impact the passing game, favoring whichever team establishes the run first.
AFC West Standings (Through Week 8)
| Team | Record | Win % | Points For | Points Against |
|---|---|---|---|---|
| Denver Broncos | 6-2 | .750 | 207 | 151 |
| Los Angeles Chargers | 5-3 | .625 | 188 | 173 |
| Kansas City Chiefs | 5-3 | .625 | 214 | 131 |
| Las Vegas Raiders | 2-5 | .286 | 103 | 180 |
The Chiefs remain firmly in playoff contention but are under pressure to keep pace in a tightly packed AFC West. Meanwhile, the Bills are chasing the top seed in the AFC East.
Prediction
Expect another classic between two of the league’s best offenses. The Bills’ home crowd gives them an edge early, but Mahomes’ late-game magic has proven nearly unstoppable in high-stakes situations.
Projected Final Score: Chiefs 30, Bills 27