NFL football returns tonight with a Week 2 Thursday Night Football matchup between the Detroit Lions and Buffalo Bills.
The Lions travel to Orchard Park, New York, to face the Bills on Thursday, September 17, 2026, with kickoff scheduled for 8:15 p.m. ET.
What NFL Teams Play Tonight?
There is one NFL game scheduled for tonight:
Detroit Lions at Buffalo Bills
Date: Thursday, September 17, 2026
Kickoff Time: 8:15 p.m. ET
Location: Highmark Stadium, Orchard Park, New York
Week: NFL Week 2
Game: Thursday Night Football
TV/Streaming: Prime Video
Both Detroit and Buffalo enter the Thursday night matchup at 1-0, giving the Week 2 game an early-season battle between two undefeated teams.
Where to Watch Lions vs. Bills Tonight
NFL fans can watch the Detroit Lions vs. Buffalo Bills Thursday Night Football game on Prime Video.
Coverage leads into the scheduled 8:15 p.m. ET kickoff.
Because Thursday Night Football is primarily streamed through Prime Video, viewers will generally need access to Amazon Prime or a standalone Prime Video subscription to watch the national broadcast.
Lions vs. Bills at Highmark Stadium
The matchup also carries additional significance for Buffalo, as the Bills are playing their first regular-season game at the new Highmark Stadium.
That makes Lions vs. Bills more than just another Week 2 matchup, with Buffalo getting an opportunity to open regular-season play at its new home in front of a national Thursday Night Football audience.
What Time Does Thursday Night Football Start Tonight?
Thursday Night Football between the Detroit Lions and Buffalo Bills starts at 8:15 p.m. ET on Thursday, September 17.
For viewers in other U.S. time zones, kickoff is scheduled for:
Eastern Time: 8:15 p.m.
Central Time: 7:15 p.m.
Mountain Time: 6:15 p.m.
Pacific Time: 5:15 p.m.
NFL Game Tonight: Lions vs. Bills
The Detroit Lions and Buffalo Bills are the only NFL teams playing tonight, giving football fans a standalone Week 2 matchup to begin the week’s NFL action.
With both teams entering at 1-0 and Buffalo playing its first regular-season game at the new Highmark Stadium, Lions vs. Bills provides plenty of intrigue for Thursday Night Football.
NFL game tonight: Detroit Lions at Buffalo Bills
Date: September 17, 2026
Time: 8:15 p.m. ET
Where to watch: Prime Video
Stadium: Highmark Stadium in Orchard Park, New York