McCaffrey rushed for 114 yards and two scores in the first half, and the 49ers built a 21-point lead by halftime in rolling to a 31-13 victory over the Seahawks on Thursday night.
The 49ers (8-3) won their fourth straight against their division rivals and have a two-game lead in the NFC West over Seattle. San Francisco won its third in a row overall following a three-game losing streak and picked up its 10th consecutive victory against a division opponent.
McCaffrey was terrific, running through arm tackles and breaking off a handful of big plays. He rushed for touchdowns of 8 and 1 yards as the 49ers built a 24-3 halftime advantage.