The Buffalo Bills (4-0) host the New England Patriots (2-2) in a primetime AFC East battle on Sunday Night Football. With Josh Allen and the Bills off to a perfect start and rookie QB Drake Maye leading the Patriots, this divisional rivalry should deliver fireworks at Highmark Stadium.
Game Information
- Matchup: New England Patriots at Buffalo Bills
- Date & Time: Sunday, October 5, 2025 – 8:20 p.m. ET
- Venue: Highmark Stadium – Orchard Park, NY
- Weather: 72°F (via AccuWeather)
- TV Channel: NBC
Betting Odds (via ESPN BET Sportsbook)
- Spread: Bills -7.5 (-105) | Patriots +7.5 (-115)
- Moneyline: Bills -400 | Patriots +300
- Total (Over/Under): 49.5 points (Over -110, Under -110)
Buffalo enters as more than a touchdown favorite, reflecting their dominance through the first month of the season.
Season Leaders
New England Patriots
- Passing: QB Drake Maye – 988 yards, 7 TDs, 2 INTs (91/123)
- Rushing: RB Rhamondre Stevenson – 125 yards (31 carries)
- Receiving: WR Stefon Diggs – 213 yards, 2 TDs (19 receptions)
- Defense: LB Harold Landry III – 3.5 sacks
Buffalo Bills
- Passing: QB Josh Allen – 964 yards, 7 TDs, 1 INT (85/121)
- Rushing: RB James Cook – 401 yards, 5 TDs (75 carries)
- Receiving: WR Keon Coleman – 203 yards, 1 TD (17 receptions)
- Defense: DT DaQuan Jones – 2 sacks
Key Storylines
- Allen vs. Maye: The veteran MVP candidate against the rookie sensation — a quarterback battle that could define the night.
- Ground Game Advantage: James Cook has been a workhorse for Buffalo, already scoring five touchdowns, while New England’s rushing attack has struggled.
- Stefon Diggs Factor: Though now in a Patriots uniform, Diggs remains a game-changer, and his revenge-game narrative against his former team adds drama.
- Primetime Bills: Buffalo has thrived in night games, and Orchard Park’s home-field advantage makes it one of the toughest places to play under the lights.
Prediction Outlook
The Bills are clicking on both sides of the ball, making them tough to beat at home. For the Patriots to stay competitive, Drake Maye must limit mistakes and connect often with Diggs. Buffalo’s balance and firepower, however, make them strong favorites to remain unbeaten.