The San Francisco 49ers take on the Tampa Bay Buccaneers in one of the marquee matchups of Week 6. Both teams enter the game at 4-1, making this a pivotal NFC clash with early playoff implications. With Christian McCaffrey powering San Francisco and Baker Mayfield leading Tampa Bay’s offense, this game is set to deliver fireworks at Raymond James Stadium.
Game Information
- Matchup: San Francisco 49ers (4-1) vs. Tampa Bay Buccaneers (4-1)
- Date/Time: Sunday, October 12, 2025 – 4:25 PM ET
- Venue: Raymond James Stadium, Tampa, FL
- TV Broadcast: CBS
- Weather Forecast: 85°F, sunny (via AccuWeather)
49ers vs. Buccaneers Odds (via ESPN BET)
- Spread: Buccaneers -2.5 (-135), 49ers +2.5 (+112)
- Total Points: 47.5
- Over 47.5: -110
- Under 47.5: -110
- Moneyline: 49ers +135, Buccaneers -155
Oddsmakers give Tampa Bay the home-field edge, but San Francisco’s balanced attack makes this one of the most evenly matched games of the week.
Season Leaders
San Francisco 49ers
- Passing: Mac Jones – 905 yards, 6 TDs, 1 INT
- Rushing: Christian McCaffrey – 282 yards, 3 TDs
- Receiving: Christian McCaffrey – 387 yards, 3 TDs
Tampa Bay Buccaneers
- Passing: Baker Mayfield – 1,283 yards, 10 TDs, 1 INT
- Rushing: B. Irving – 237 yards, 2 TDs (Questionable)
- Receiving: Emeka Egbuka – 445 yards, 5 TDs
San Francisco’s offense has revolved around McCaffrey’s dual-threat ability, while Mayfield has been sharp through five games, finding Egbuka as his top target.
Key Storylines to Watch
- QB Battle: Mac Jones has been steady for San Francisco, but Mayfield is playing some of the best football of his career with 10 touchdowns already.
- McCaffrey Factor: The 49ers will continue to lean on Christian McCaffrey as both a rusher and receiver, making him the biggest X-factor in this game.
- Tampa’s Offensive Balance: If B. Irving can play through his injury, the Buccaneers’ offense will be harder to contain; if not, Mayfield may have to carry the load.
- Playoff Implications: Both teams are 4-1, meaning the winner will grab a strong hold on NFC playoff positioning.
Prediction
This game has the feel of a playoff preview. Tampa Bay’s home-field advantage and Mayfield’s hot start give them the slight edge, but San Francisco’s defense and McCaffrey’s versatility make this a true toss-up. Expect a close battle that could be decided in the fourth quarter.
Pick: Buccaneers 27, 49ers 24
Final Word
Catch the San Francisco 49ers vs. Tampa Bay Buccaneers on CBS at 4:25 PM ET, Sunday, October 12, 2025, live from Raymond James Stadium. With two 4-1 teams colliding, this NFC showdown is one of the top games of Week 6 and could have major playoff implications.