The San Francisco 49ers (5–3) head to MetLife Stadium to face the New York Giants (2–6) in a pivotal Week 9 matchup on Sunday, November 2, 2025. The 49ers are fighting to keep pace in the NFC West race, while the Giants look to regroup after losing one of their most important offensive pieces.
Game Information
- Matchup: San Francisco 49ers vs. New York Giants
- Date: Sunday, November 2, 2025
- Time: 1:00 PM ET
- Venue: MetLife Stadium — East Rutherford, NJ
- TV Channel: CBS
- Temperature: 54°F (via AccuWeather)
How to Watch
- TV: CBS
- Streaming: Paramount+ (with CBS access) or CBS Sports App
- Location: MetLife Stadium, East Rutherford, NJ
This early-window CBS game will reach millions of viewers across the East Coast. Fans can also stream the matchup on Paramount+ with a live TV subscription.
Betting Odds (via ESPN Bet Sportsbook)
- Spread: 49ers –2.5 (–125) | Giants +2.5 (+105)
- Moneyline: 49ers –150 | Giants +130
- Total (Over/Under): 48.5 points
- Over: –110
- Under: –110
According to ESPN Analytics, New York holds a 56.2% chance to win, while San Francisco sits at 43.5%, suggesting a competitive matchup despite the injury news.
Team Leaders
| Category | San Francisco 49ers | New York Giants |
|---|---|---|
| Passing Yards | M. Jones – 1,597 (8 TD, 5 INT) | J. Dart – 984 (8 TD, 3 INT) |
| Rushing Yards | C. McCaffrey – 490 (3 TD) | Out: C. Skattebo (410 yards, 5 TD, ankle injury) |
| Receiving Yards | C. McCaffrey – 559 | W. Robinson – 494 |
| Sacks | B. Huff – 4 | B. Burns – 10 |
Key Storylines
- Cameron Skattebo out for the season: The Giants’ leading rusher Cameron Skattebo has been ruled out for the year after suffering a season-ending ankle injury. His absence leaves a major void in New York’s backfield, forcing the team to lean on rookie backups and short-yardage formations.
- 49ers look to regain rhythm: Quarterback Mac Jones remains listed as questionable, but if he plays, his connection with Christian McCaffrey will be key.
- Defensive battle brewing: Giants linebacker Brian Burns, who leads with 10 sacks, will be a major factor in containing San Francisco’s offense.
Matchup Outlook
Without Skattebo, the Giants’ offense faces a tough challenge against a 49ers front seven that thrives on pressure and run defense. Expect the Giants to rely more on short passing and tempo to offset their missing ground game. Meanwhile, McCaffrey’s dual-threat presence gives the 49ers a balanced attack capable of exploiting mismatches.
Prediction
The Giants will struggle to replace Skattebo’s production, and the 49ers’ defense should capitalize. If Mac Jones starts, San Francisco’s offensive versatility gives them a strong advantage on the road.
Projected Final Score: 49ers 27, Giants 17