The SEC delivers another marquee matchup in Week 5 as the No. 3 LSU Tigers (4-0) travel to Oxford to face the No. 13 Ole Miss Rebels (4-0). Both teams enter undefeated, setting the stage for a Top-15 clash with major College Football Playoff implications.
Game Information
- Matchup: No. 3 LSU Tigers vs. No. 13 Ole Miss Rebels
- Date: Saturday, September 27, 2025
- Kickoff Time: 3:30 PM ET
- Location: Vaught-Hemingway Stadium – Oxford, MS
- TV Channel: ABC
- Streaming Options: Watch live on the ABC app, ESPN app, or through providers like Fubo (free trial), Hulu + Live TV, Sling TV, and YouTube TV.
Betting Odds (via BetMGM)
- Opening Line: LSU -1.5
- Against the Spread (ATS): LSU 2-2 | Ole Miss 3-1
Key Stats Breakdown
LSU Tigers
- Offense:
- Total: 391.3 yards per game (71st in FBS)
- Passing: 274.5 ypg (31st)
- Rushing: 116.8 ypg (112th)
- Scoring: 29.0 ppg (77th)
- Defense:
- Total: 246.3 ypg allowed (17th)
- Passing: 182.3 ypg (43rd)
- Rushing: 64.0 ypg (10th)
- Scoring: 9.3 ppg (9th)
- Extra Edge: LSU ranks 15th nationally in third down defense (24.5%) and has a +2 turnover margin.
Ole Miss Rebels
- Offense:
- Total: 543.3 yards per game (9th in FBS)
- Passing: 324.8 ypg (14th)
- Rushing: 218.5 ypg (25th)
- Scoring: 44.8 ppg (12th)
- Defense:
- Total: 356.8 ypg allowed (72nd)
- Passing: 166.3 ypg (25th)
- Rushing: 190.5 ypg (121st)
- Scoring: 18.8 ppg (42nd)
- Extra Edge: Ole Miss ranks 23rd in red zone defense (71.4%), though they struggle in time of possession (109th nationally).
Team Leaders
LSU Tigers
- QB Garrett Nussmeier: 960 yards, 6 TDs, 2 INTs (68.6% comp)
- RB Caden Durham: 213 yards, 2 TDs
- WR Aaron Anderson: 293 yards on 21 catches
Ole Miss Rebels
- QB Trinidad Chambliss: 719 yards, 4 TDs, 0 INTs (67.7% comp)
- RB Kewan Lacy: 358 yards, 7 TDs
- WR Harrison Wallace III: 343 yards, 2 TDs
Last Game Recap
- LSU: Rolled past Southeastern Louisiana 56-10. Nussmeier threw for 273 yards and 3 TDs while adding a rushing score. Ju’Juan Johnson added two rushing TDs.
- Ole Miss: Dominated Tulane 45-10. Chambliss accounted for 419 total yards (307 passing, 112 rushing) and two touchdowns. Lacy added two rushing TDs, while Deuce Alexander caught four passes for 94 yards and a touchdown.
Keys to the Game
- LSU’s Defense vs. Ole Miss’ Offense: LSU ranks top-10 in scoring defense, but Ole Miss is a top-10 unit in total offense. Something has to give.
- QB Play: Nussmeier’s efficiency will be tested against Ole Miss’ secondary, while Chambliss must avoid LSU’s defensive pressure.
- Turnovers & Red Zone: LSU holds the advantage in turnover margin, but Ole Miss’ stingy red zone defense could swing momentum.
Prediction
This matchup pits LSU’s elite defense against one of the most explosive offenses in the country. The Rebels’ rushing attack and Chambliss’ dual-threat ability make them dangerous at home, but LSU’s balance and defensive discipline give them the edge.