Menu
The Sports Cast
  • Home
  • About
    • Privacy Policy
    • Newsletter
    • Links
  • Sections
    • College Basketball
    • College Football
    • Pro Football
    • Pro Basketball
    • Soccer
  • Podcasts
    • The Update
    • Jersey Boys Sports Talk
    • The Donut Bag
    • Listen Live
  • Shop
    • T-shirts
    • Sweaters
    • Hats
    • Mugs
  • TV Schedules
    • NFL Schedule TV Schedule
    • NFL on TV Today
  • Contact
  • Advertise with Us
The Sports Cast

Follow Us

Listen to Podcast

  • YouTube
  • iTunes
  • Spotify
  • TuneIn


How to Watch San Francisco 49ers vs. Los Angeles Rams: TV Channel, Streaming, Odds, and Key Matchups

Posted on September 30, 2025September 30, 2025 by Santiago Leon

The San Francisco 49ers travel south to face the Los Angeles Rams in a prime-time NFC West showdown. With playoff implications already looming, here’s everything you need to know about how to watch the game, betting odds, injury updates, and key stats heading into kickoff.


Game Details

  • Matchup: San Francisco 49ers at Los Angeles Rams
  • Venue: SoFi Stadium – Inglewood, CA
  • Date & Time: 8:15 p.m. ET
  • TV Channel: Amazon Prime Video
  • Streaming (in-market viewers): Fubo – Stream now
  • Tickets: Available on StubHub

Latest Odds (via BetMGM)

  • Spread: Rams -5.5 (-110), 49ers +5.5 (-110)
  • Moneyline: Rams -250 | 49ers +200
  • Total (Over/Under): 47 points (Over -110, Under -110)

The Rams enter as clear favorites at home, but divisional matchups between San Francisco and Los Angeles often bring surprises.


Injury Reports

Los Angeles Rams

  • TE Tyler Higbee – DNP (Hip)
  • S Kamren Kinchens – Limited (Shoulder)
  • TE Colby Parkinson – Full (Shoulder)
  • OL Rob Havenstein – DNP (Ankle)

San Francisco 49ers

  • LB Dee Winters – Limited (Knee)
  • DE Mykel Williams – Limited (Wrist)
  • DT CJ West – DNP (Thumb)
  • WR Jordan Watkins – DNP (Calf)
  • QB Brock Purdy – DNP (Toe)
  • WR Ricky Pearsall – DNP (Knee)
  • OL Colton McKivitz – Full (Calf)
  • QB Mac Jones – Full (Knee)
  • WR Jauan Jennings – DNP (Ankle)
  • CB Renardo Green – Limited (Neck)
  • DL Robert Beal – DNP (Ankle)

Key Stats to Watch

  • The Rams average 25 points per game, over six more than the 49ers typically allow.
  • Los Angeles racks up 388.3 yards per game, while San Francisco has held opponents to just 280.5 yards.
  • The 49ers score 20 points per game, nearly identical to the 20.3 points the Rams give up.
  • San Francisco’s offense gains 368 yards per game, nearly 84 more yards than the Rams’ defense surrenders (284.5).
  • Efficiency battle: LA averages 6.3 yards per play, while SF’s defense allows only 4.7 yards per play.

Prediction Outlook

The Rams’ high-powered offense will test San Francisco’s stingy defense, while injuries to 49ers playmakers — especially QB Brock Purdy — could tilt the balance toward Los Angeles. Expect a close divisional contest with playoff positioning at stake.

Related

Related posts:

  1. Episode #197: NFL Outlines Plans for Ticket Refund Policy and Teams Prepare to Limit Ticket Sales
  2. Mike Evans contract disputes with Bucs | The Update with Santiago Leon and Ryan Christa
  3. Michigan Becomes First School to Have First-Round Picks in NFL, NBA, MLB, NHL, and MLS Drafts in Same Year
  4. J.J. Watt’s Sports Team Ownership: Burnley F.C. and RCD Espanyol
Advertisements

Products

  • Dillon Gabriel Tee Dillon Gabriel Tee $30.29 – $36.29Price range: $30.29 through $36.29
  • The Big Dumper Tee The Big Dumper Tee $29.60 – $31.60Price range: $29.60 through $31.60
  • Marc Cucurella Tee Marc Cucurella Tee $30.69 – $36.69Price range: $30.69 through $36.69

DOWNLOAD THE SPORTS CAST APP for iOS

Show Lineup

Mondays 12pm & Fridays 12pm

The UPDATE w/Santiago Leon

Mondays 8pm

The Donut Bag – Steelers Talk hosted by Joey Bag of Donuts

Thursdays at 8pm ET

Jersey Boys Sports Talk hosted by Victor Arocho & Byron Jones

LIVE on Twitter, Facebook, Twitch and YouTube

Ad - Web Hosting from SiteGround - Crafted for easy site management. Click to learn more.

Subscribe to our mailing list

* indicates required


Archives

Categories

  • Announcements
  • Baseball
  • Byron Jones NFL Mock Draft 2021
  • College Basketball
  • College Football
  • Fighting
  • Golf
  • Hockey
  • Media
  • News
  • NFL Mock Drafts
  • Podcast
  • Pro Basketball
  • Pro Football
  • Racing
  • Schedules
  • Soccer
  • Tennis
  • Wrestling

FOLLOW US

©2025 The Sports Cast | Powered by Superb Themes