The San Francisco 49ers travel south to face the Los Angeles Rams in a prime-time NFC West showdown. With playoff implications already looming, here’s everything you need to know about how to watch the game, betting odds, injury updates, and key stats heading into kickoff.
Game Details
- Matchup: San Francisco 49ers at Los Angeles Rams
- Venue: SoFi Stadium – Inglewood, CA
- Date & Time: 8:15 p.m. ET
- TV Channel: Amazon Prime Video
- Streaming (in-market viewers): Fubo – Stream now
- Tickets: Available on StubHub
Latest Odds (via BetMGM)
- Spread: Rams -5.5 (-110), 49ers +5.5 (-110)
- Moneyline: Rams -250 | 49ers +200
- Total (Over/Under): 47 points (Over -110, Under -110)
The Rams enter as clear favorites at home, but divisional matchups between San Francisco and Los Angeles often bring surprises.
Injury Reports
Los Angeles Rams
- TE Tyler Higbee – DNP (Hip)
- S Kamren Kinchens – Limited (Shoulder)
- TE Colby Parkinson – Full (Shoulder)
- OL Rob Havenstein – DNP (Ankle)
San Francisco 49ers
- LB Dee Winters – Limited (Knee)
- DE Mykel Williams – Limited (Wrist)
- DT CJ West – DNP (Thumb)
- WR Jordan Watkins – DNP (Calf)
- QB Brock Purdy – DNP (Toe)
- WR Ricky Pearsall – DNP (Knee)
- OL Colton McKivitz – Full (Calf)
- QB Mac Jones – Full (Knee)
- WR Jauan Jennings – DNP (Ankle)
- CB Renardo Green – Limited (Neck)
- DL Robert Beal – DNP (Ankle)
Key Stats to Watch
- The Rams average 25 points per game, over six more than the 49ers typically allow.
- Los Angeles racks up 388.3 yards per game, while San Francisco has held opponents to just 280.5 yards.
- The 49ers score 20 points per game, nearly identical to the 20.3 points the Rams give up.
- San Francisco’s offense gains 368 yards per game, nearly 84 more yards than the Rams’ defense surrenders (284.5).
- Efficiency battle: LA averages 6.3 yards per play, while SF’s defense allows only 4.7 yards per play.
Prediction Outlook
The Rams’ high-powered offense will test San Francisco’s stingy defense, while injuries to 49ers playmakers — especially QB Brock Purdy — could tilt the balance toward Los Angeles. Expect a close divisional contest with playoff positioning at stake.